Welcome to the Integrative Neurophysiology Laboratory Website

Mission Statement

To identify the neuromuscular mechanisms of human fatigue and physical disability.


The current research at INPL focuses on developing a clearer understanding of fatigue and disability and the treatments in people with Multiple Sclerosis (MS). We also focus on investigating new therapeutic approaches to neurological diseases.

The current basic laboratory research focuses on the following areas:

  1. Investigating the effects of cannabis use in patients with MS on motor and cognitive functions.
  2. Exploring the positive and negative effects of cannabis on quality of life and disability in neurological diseases (e.g. Parkinson’s disease, Multiple Sclerosis, Dementia).
  3. Clarifying the origins of MS related fatigue.
  4. The use of non-invasive neuroimaging techniques (Positron Emission Tomography, Computed Tomography, Magnetic Resonance Imaging) to examine the CNS–skeletal muscle interaction at a whole-body level.

Lab News

  • Big News: The Germans are leaving the HES department this summer! Dr. Rudroff accepted a position at the University of Iowa. Felix Proessl will start his PhD at the University of Pittsburgh.
  • INPL received a Pilot Grant from the National Multiple Sclerosis Society "Can Transcranial Direct Stimulation Improve Walking in Multiple Sclerosis?"
  • John Kindred successfully defended his PhD Thesis. Congrats Dr. Kindred! He is now a Postdoctoral Research Scholar in the Department of Physical Therapy at Medical University of South Carolina.
  • Dr. Rudroff was appointed to the faculty of the University of Colorado School of Medicine-Department of Radiology/Nuclear Medicine as Adjoint Assistant Professor.
  • Dr. Rudroff and his team received the 2017 CCTSI CSU Pilot Gant : Transcranial Direct Current Stimulation to Lower Neuropathic Pain in People with Multiple Sclerosis: A Mechanistic PET Study.
  • Dr. Rudroff and his colleagues from Anschutz Medical Campus, Denver, Drs. Jennifer Kwak (Nuclear Medicine) and Justin Honce (Neuroradiology) received a grant from the Colorado Translational Research Imaging Center (C-TRIC) to investigate "Effects of regular cannabis smoking on resting brain function in people with multiple sclerosis: An observational FDG-PET study".

Names left to right: INP Lab: Nathan Ketelhut, Felix Proessl, Thorsten Rudroff, John Kindred, and Kelly Oberg